Forensic Science Seminar
Peer-reviewed forensic science journal · Established 2011
ISSN 2157-118XFOREN SCI SEM · Volume 1

Abstracts · Abstract A4

The Bioinformatics Analysis of Human Glucocoiticoid Receptor Regulated Target Genes

Alternate published title: 人糖皮质激素受体靶基因的生物信息学分析

Ling Zeng, Wei Gu, Jun Yan, Haiyan Wang, Jianyun Zhou, Jianxin Jiang

Forensic Science Seminar · 2011 · Volume 1 · Issue 1 · pp. 30

Peer ReviewedISSN 2157-118X Issue date 1 January 2011Public HTML Record
Complete Issue PDF · File A Complete Issue PDF · File B Back to Volume 1, Number 1

Original Abstract

Abstract

Objective To identify the distribution and function of glucocoiticoid receptor (GR) regulated target genes in the human genome, and to know the bioinformatic significance of it. Methods With bioinformatics methods, we found out all the genes that contains Glucocorticoid Response Element’s (GRE) consensus sequences, and extend our study to the distribution of consensus sequences in the human genome and the functions, protein products and the Gene Ontology (GO) number of the GR target genes and then to emphasize these genes’ function in inflammation and immunity. Results We found 225 genes which contain the GRE-1 consensus sequence (5’-AGAACAnnnTGTTCT-3’) and 94 genes contain GRE-2 consensus sequence (5’-GGTACAnnnTGTTCT-3’). Conclusion According to the analysis of the function of genes which contain the consensus sequence of GRE, F2R, DAXX, PAG1, ULBP3, OR8D4, RIMS1, NPY2R are correlate with inflammation and immunity.

Keywords: Glucocorticoid; Glucocorticoid Receptor; Glucocorticoid Response Element; Consensus sequence of GRE; Bioinformatics

The original published wording is preserved. No editorial rewriting has been applied.

Authors & Publication

Article Details

Affiliations
  1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China.

Corresponding author: Jianxin Jiang

Source contact details: Tel/Fax: +86 023 68706323; E-mail: hellojjx@126.com (Prof. Jianxin Jiang); zengling_1025@126.com (Ling Zeng, PhD); Zip code: 400042.

Received15 September 2010
Revised29 October 2010
Accepted31 October 2010
Available Online1 January 2011
Source note: The title spelling “Glucocoiticoid” is preserved exactly as printed in the English source title.

Citation Information

Document codeA4 · Abstract
JournalForensic Science Seminar
ISSN2157-118X
Volume / Issue1 / 1
Pages30
Official issue date1 January 2011
Article HTMLhttps://fss.xxyy.info/journal/2011/2157118X.1.A4.html
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